Design or find a Supplement to remove Gadolinium Gd3+ from the human body. Detox. Chelation . It must have a High stability constant.

Closed Posted Nov 30, 2015 Paid on delivery
Closed Paid on delivery

Create a new organic supplement

or find a existing supplment that will bind with Gd3+ ions Gadolinium in the human body and remove them from the body.

EDTA is not good enough because it's stability constant is to close to Zinc.

It is proposed that some other organic acids may have a very high affinity and stability constant for Gd3+

Malic Acid

Galactaric Acid

Clucaric Acid

Is Cilantro effective.

Need to test effects of different compounds on Gd3+ ions

I believe nature already has this answer without having to resort to DTPA

The Gd3+ ions left in the bodies after MRI Gadolinium contrast agents are mainly bound to Phosphorous. GdPO4 and the rest is Free Gd3+ ions. . Some may be bound to citrates, albumin, etc.

I believe that GdPO4 logk = 12.5 but not sure.

but, if the free Gd3+ ions are forming GdPO4H2O then the logk= 25 I think

But we are not sure.

DTPA has a conditional stability of 17.5.

I am looking to find a better chelator then DTPA for Gd that is natural and I can sell as a supplement.

Organic Acid compounds may have the ability to cross the BBB blood brain barrier as well and remove gd from the brain.

Gd3Galactarate2 is proposed as having a logk = 30

Perhaps a Ca3Galactarate2 complex can be created to take as a supplment and exchange the Ca for Gd

Also

Gd-Malate with a composition of [url removed, login to view] has been shown to have a logk of 31

Could we create [url removed, login to view] and use as a chelator for Gd?

These are some Ideas. We could need to do some testing.

Chemical Engineering

Project ID: #9003856

About the project

1 proposal Remote project Active Jan 6, 2016

1 freelancer is bidding on average $750 for this job

suyashdhoot

Hi I am Msc in food biotechnology, microbiology and analytical chemistry. I have excellent knowledge of these subjects and 7years research and formulation experience. I have worked with food companies, cosmetics and ph More

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